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The first published efficacy trial of sildenafil involved only 12 patients, but it is the only study that included objective measurements of penile rigidity.20 In the first phase of this study, penile rigidity was measured using plethysmography during visual sexual stimulation in patients taking varying doses of sildenafil or placebo. In the men who took the 50-mg dose of sildenafil, the mean duration of erection was increased by 10 minutes at the base of the penis and six minutes at the tip of the penis compared with placebo. The second phase of this study involved a diary of erectile activity in which 10 of 12 patients reported improved erectile activity while receiving sildenafil.
A few causes of impotence may be iatrogenic (medically caused). Various antihypertensives (medications intended to control high blood pressure) and some drugs that modify central nervous system response may inhibit erection by denying blood supply or by altering nerve activity.
The entire field of PDE investigation has received enormous benefits from recent technological innovations. New tools have helped to overcome some problems that have plagued the field. For example, the high degree of identity among the active sites of many of the PDEs has made them challenging targets for identification of selective inhibitors. This problem is being addressed by the use of high throughput screening and X-ray crystallography. In particular the solution of several PDE catalytic domain crystal structures in the presence of drugs has yielded crucial information on the active sites of these enzymes and allowed rational design to improve inhibitor potency and selectivity. Both high throughput screening and crystallization are now able to be performed efficiently with robotics, further decreasing the cost and increasing the speed with which PDE selective inhibitors can be discovered. Unfortunately, much less effort has gone into identification of activators of PDEs although much of the same technology could be applied. At the functional level the identification of new PDE enzymes has been greatly aided by developments in molecular biology. In particular the publication of the human and mouse genomes has led to the discovery of new PDE isoforms and the identification of variants of previously known ones. These advances have implicated the involvement of PDEs in many pathological conditions. Newer genetic techniques for probing PDE function such as RNA interference and tissue-specific conditional mouse gene disruptions and conditional RNA interference expression should allow for the validation of newly discovered enzymes as targets in specific diseases and forewarn of potential inhibitor side effects.
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Men who have had a heart attack or stroke within the past 6 months and those with certain medical conditions (e.g., uncontrolled high blood pressure, severe low blood pressure or liver disease, unstable angina) that make sexual activity inadvisable should not take Cialis®. Dosages of the drug should be limited in patients with kidney or liver disorders.
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Treatment for an undescended testicle depends on where it is. Babies who have a testicle that can be felt in the groin (the area where your thigh meets your body) often get an operation called orchiopexy (say: "or-key-oh-peck-see"). Babies who have this operation usually go home the same day. The operation is done through a small cut in the groin. Most babies get better very quickly.
Bulbocavernosus reflex: This test evaluates nerve sensation in the penis. During the test, your doctor will squeeze the head of your penis, which should immediately cause your rectum to contract. If nerve function is abnormal, there will be a delay in response time or absence of rectal contraction.
Occurs after you start taking a new medicine or change the dose of a medicine.
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There are many underlying physical and psychological causes of erectile dysfunction. Reduced blood flow to the penis and nerve damage are the most common physical causes. Underlying conditions associated with erectile dysfunction include the following:
They typically contain stearate, croscarmellose, calcium hydrogen phosphate (anhydrous), and microcrystalline cellulose. After all, this can be not the entire formulation as it is a closely guarded secret of each manufacturer.
The key, she says, is in the intentionality. "You have to go into it with the attitude of 'playing,' not fixing your sex life. It's all in the intentionality," Foley tells WebMD.
This is similar to magnetic resonance imaging. Magnetic resonance angiography uses magnetic fields and radio waves to provide detailed images of the blood vessels. Doctors may inject a "contrast agent" into the patient's bloodstream that causes vascular tissues to stand out against other tissues. The contrast agent provides for enhanced information regarding blood supply and vascular anomalies. Aside from the IV used to introduce the contrast material into the bloodstream, magnetic resonance angiography is noninvasive and painless.
A phase 1 trial of one vaccine appeared to promote immune responses in 70 percent of the patients involved, according to a recent study.
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Ejaculation, the release of semen at climax, is triggered when the man reaches a critical level of excitement. Sexual stimulation causes nerves in the penis to send chemical messages or impulses to the spinal cord and into the brain. There, more chemical messages are sent back to the penis causing ejaculation.
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